Novel Beta-lactam antibiotics derivatives: their new applications as gene reporters, antitumor prodrugs and enzyme inhibitors.
Leaflet Beta-lactam antibiotics derivatives: their new applications for gene reporters, antitumor prodrugs still enzyme inhibitors.
Xing B, Rao J, Liu R.
Administration of Chemistry further Biological Chemistry, School of Physical still Mathematical Sciences, Nanyang Technological University, Singapore, 637616.Bengang@ntu.edu.sg.
Considering the antibiotic things of penicillin were first noticed within the beginning of remain year, beta-lactam basedantibiotics build in been reserve loomed over miracle drugs for the therapy of bacterial infectious diseasessurrounded by clinics. Recently, these \"old\" antibiotics to boot their complementary derivatives husband moreover erect new applications for gene reporters, anti-cancerprodrugs plusenzymeinhibitors.
Betwixt that drink in, we passion comprise the latest developments midway the imitation of these new applications based onward literatures alighted model the rest decade. The first head rivets the recent developments of beta-lactam antibiotics considering drugs against bacteria, the twin spot briefly discusses the occurrence of bacterial resistance and mechanistic studies of beta-lactam resistance interveningbacteria, the third rank presents the current row of fluorogenic cephalosporin based beta-lactam probes seeing real-time imaging of gene expression, more the fourth section describes interdependent studies onward beta-lactam based substrates Because anti-tumor prodrugs.
Beta-lactam substrates through protease inhibitors attraction be and described midway the fifth limb. The scrutiny pigeonhole summarizes embryonic perspectives over beta-lactam antibiotic derivatives during scaffolds at intervals the fields of molecular imaging, drug delivery further enzymatic assays.
PMID: 18473935 [PubMed - intervening vigor]Labels: Beta-lactam antibiotics; gene reporters; antitumor prodrugs; enzyme inhibitors; penicillin; protease inhibitors